Description
Retatrutide 20mg | Triple Receptor Agonist (GLP-1, GIP & Glucagon)
IMPORTANT: RESEARCH USE ONLY
Retatrutide is supplied as a lyophilized peptide powder intended exclusively for scientific and laboratory research purposes (Research Use Only, RUO).
This material is not intended for human or veterinary use, human consumption, diagnostic procedures, or therapeutic applications.
Also Known As: Retatrutide, LY3437943, LY-3437943, Triple G Agonist, Triple Incretin Agonist
PRODUCT OVERVIEW
Retatrutide is a synthetic peptide currently under investigation for its activity as a triple receptor agonist targeting the GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), and glucagon receptors.
Its simultaneous activity across three metabolically relevant receptor pathways has made retatrutide a compound of interest in research involving receptor pharmacology, metabolic regulation, energy homeostasis, endocrine signalling, glucose metabolism, and energy expenditure.
Experimental research may investigate receptor activation, downstream intracellular signalling, metabolic pathways, receptor interactions, structure-activity relationships, and other mechanisms associated with multi-receptor agonism under controlled laboratory conditions.
The compound is also of interest for comparative research examining the differences between single, dual, and triple receptor agonism across metabolically relevant signalling pathways.
Each vial contains 20mg of Retatrutide in lyophilized form.
RESEARCH BACKGROUND
Retatrutide, also known by the development designation LY3437943, is an investigational peptide developed for simultaneous activity at three metabolically relevant receptor systems.
These include the GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR).
Each receptor participates in distinct but interconnected aspects of metabolic and endocrine signalling. Combining activity across all three receptors has therefore generated considerable research interest in the biological consequences of coordinated multi-receptor activation.
Retatrutide continues to undergo scientific and clinical investigation, providing opportunities for research into receptor pharmacology, metabolic signalling, and the molecular characteristics of multi-receptor peptide agonists.
MECHANISM OF RESEARCH INTEREST
Retatrutide is primarily of research interest because of its triple receptor agonist activity.
Its interaction with GLP-1, GIP, and glucagon receptors enables researchers to investigate how simultaneous receptor activation influences downstream signalling pathways and metabolic processes.
The GLP-1 and GIP receptors are associated with incretin and metabolic signalling, while the glucagon receptor participates in glucose and energy metabolism.
Studying coordinated activity across these receptor systems may provide insight into receptor interactions, intracellular signalling, metabolic regulation, energy homeostasis, and endocrine pathway integration.
The precise biological responses observed depend on experimental conditions, receptor expression, concentration, model system, and other laboratory variables.
RESEARCH APPLICATIONS
- GLP-1 receptor pharmacology
- GIP receptor pharmacology
- Glucagon receptor pharmacology
- Triple receptor agonist research
- Multi-receptor signalling studies
- Receptor activation investigations
- Intracellular signalling research
- Metabolic regulation studies
- Energy homeostasis research
- Endocrine signalling investigations
- Cell-based receptor signalling assays
- Preclinical metabolic research models
- Glucose metabolism research
- Energy expenditure studies
- Structure-activity relationship (SAR) research
- Comparative incretin receptor research
PRODUCT SPECIFICATIONS
Product Name: Retatrutide
Development Name: LY3437943
Active Ingredient: Retatrutide
Compound Type: Triple Receptor Agonist Peptide
Receptor Targets: GLP-1R, GIPR and GCGR
CAS Number: 2381089-83-2
UNII: NOP2Y096GV
Chemical Formula: C221H342N46O68
Molecular Weight: Approximately 4731 g/mol
Peptide Length: 39 amino acids
Appearance: White to off-white lyophilized powder
Physical Form: Lyophilized Powder
Quantity: 20mg per vial
Product Classification: Research Use Only (RUO)
Packaging: Sealed research vial
STORAGE & HANDLING
- Long-Term Storage: Store at -20°C in the original sealed container for optimal long-term stability.
- Short-Term Storage: Store refrigerated at 2-8°C for up to a few months.
- Protect from direct light, excessive heat, and moisture.
- Keep the vial tightly sealed during storage.
- Minimize unnecessary temperature fluctuations.
- Avoid repeated freeze-thaw cycles.
- After Reconstitution: Store refrigerated at 2-8°C and avoid repeated temperature cycling.
- Recommended Use After Reconstitution: Use within 28 days when stored refrigerated at 2-8°C.
- Shelf Life: Up to 24 months from the date of manufacture when stored under the recommended long-term storage conditions.
Storage and stability periods should be confirmed against the applicable product documentation or Certificate of Analysis (COA).
RESEARCH SAFETY INFORMATION
Retatrutide remains an investigational compound and continues to undergo scientific and clinical evaluation.
Published clinical research involving retatrutide has reported adverse events, with gastrointestinal events among those observed, including:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort
- Decreased appetite
These observations relate to published clinical research and are included solely as scientific background. They should not be interpreted as establishing the safety or suitability of this research material for any non-research purpose.
Retatrutide research material should be handled by appropriately trained personnel using suitable laboratory procedures and personal protective equipment.
Scientific Information Notice: The information provided above is solely a summary of scientific and research information. It does not constitute medical advice, dosing guidance, treatment recommendations, administration instructions, or instructions for human use.
REGULATORY & RESEARCH USE NOTICE
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
This product is intended solely for scientific and laboratory research.
Retatrutide is an investigational compound and is not supplied as an approved medicinal product. It is not intended for human consumption, diagnosis, treatment, prevention of disease, or any clinical or therapeutic application.
Purchasers are responsible for ensuring that the purchase, possession, storage, handling, and use of this material comply with all applicable laws, regulations, institutional requirements, and laboratory safety procedures.
Product-specific information, including identity, purity, quantity, batch testing, and stability, should be referenced against the relevant Certificate of Analysis (COA).
Images for illustration purposes only.
